|
KMID : 1161420110140010173
|
|
Journal of Medicinal Food
2011 Volume.14 No. 1 p.173 ~ p.179
|
|
|
Preventive Effect of Probiotics and α-Tocopherol on Ethanol-Induced Gastric Mucosal Injury in Rats
|
|
Senol Altug
Isler Mehmet
Karahan Aynur G.
Kilic Gulden B.
Kuleasan Hakan
Kaya Selcuk
Keskin Muharrem
Goren Ibrahim
Saritas Ulku
Aridogan Buket C.
Delibas Namik
|
|
|
Abstract
|
|
|
|
The protective effect of a probiotic mixture of 13 different bacteria and α-tocopherol on 98% ethanol-induced gastric mucosal injury was evaluated. Levels of gastric mucosal pro- and anti-inflammatory cytokines, malondialdehyde, and secretory immunglobulin A were measured. Rats were allocated into four groups: control, ethanol, probiotic, and α-tocopherol. The control and ethanol groups received skim milk for 14 days. Probiotic and α-tocopherol groups were administered probiotic mixture suspended in skim milk and 100?mg/kg α-tocopherol, respectively, by daily gavage for 14 days. On Day 15, gastric lesions were induced by administration of ethanol 98% (1?mL) to all rats except those in the control group. Probiotic, but not α-tocopherol, seemed to inhibit ethanol-induced gastric mucosal tumor necrosis factor-α, interferon-γ, and interleukin-2 production (P?>?.05). Ethanol caused the elevation of mucosal interleukin-4 level (compared to the control, P?
|
|
|
KEYWORD
|
|
|
ethanol, gastric injury, probiotic, rat, α-tocopherol
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|